Endocrine Abstracts

Hashimoto’s thyroiditis is thought to result from the decreased of T helper type 2 (Th2) responses, leading to progressive destruction of thyrocytes. IFN-λ1, -λ2, and -λ3 (also known as IL-29, IL-28A, and IL-28B, respectively) is a recently described member of the IFN-λ family and has been shown to decrease production of Th2 cytokines in vitro. However, the role and mechanism of IFN-λ1 in Hashimoto’s thyroiditis remain unkno...

Aim: To evaluate serum (SMK) and nodular (NMK) midkine levels in thyroid nodules and explore its relevance to ultrasound feature/pathological results.Methods: A total of 80 patients (56 women, 24 men) with thyroid nodules were included in this prospective study. Hemograms, thyroid function tests, fine needle aspiration biopsies, ultrasonographic evaluation were routinely made. In addition, levels of SMK and NMK were measured. Any possible correlations be...

Introduction: We report a case with primary adrenocortical deficiency after the first month of lactation.Case report: Thirty-year-old woman was referred with complaints including dizziness, weakness and fatigue in the early postpartum and lactation period. On physical examination, weight 63 kg, height 164 cm, blood pressure 100/65 mmHg, pulse 96 per min were detected. She had the increase of the brown pigmentation on her hands and face. In the a...

Introduction: Serum and intranodal levels of IGF1 and IGF-binding protein 3 levels (IGFBP3) were determined in patients with nodular thyroid diseases.Materials and methods: Demographic, clinicopathological and laboratorial caracteristics of the subjects were recorded. After performing fine needle aspiration biopsy, IGF1 and IGFBP3 levels were determined in blood and aspiration samples. Clinicopathological and laboratorial findings were analysed.<p cl...

Introduction: Cushing’s disease is not likely to be pituitary apoplexy or macroadenoma. We present a case of pituitary apoplexy after dexamethasone suppression test for Cushing’s disease due to macroadenoma.Case report: A 30-year-old man complained of headache and closure of the left upper eyelid. Two years ago he had a headache, and was diagnosed with non-functional macroadenoma of pituitary. In follow, insuppressibly serum levels of cortisol ...

Introduction: Thyroid disorders such as subacute thyroiditis occur rarely in pregnancy. We report a recurrent case of subacute thyroiditis improved with the onset of pregnancy.Case report: A 32-year-old Turkish women who request pregnancy and planned insemination was referred due to malaise and neck pain in the left side a week ago. She was presented with low-grade fever, fatigue, pharingitis symptoms, neck pain and extremely tenderness in the right side...

Background: Atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is a heterogeneous that cannot be definitively diagnosed as benign, malignancy-suspect, or malignant. The estimated risk of AUS/FLUS malignancy is reported 5% to 15% according to the Bethesda System (BS). This study was conducted to evaluate the ability of mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR) to predict the malignant potential of nodules diag...

Background: Primary hyperparathyroidism (PHPT), caused by increased parathyroid hormone (PTH) secretion, leads to generalised disorder of bone metabolism characterised with hypercalcaemia and hypophosphatemia. Causes of PHPT include solitary parathyroid adenoma (80%), primary parathyroid hyperplasia (10–15%), and parathyroid carcinoma (1–2%). Other rare cause is double parathyroid adenomas (DPA) with frequency <1–2%, which can be sporadic or familial. DPA sh...

Aim: To evaluate serum and intranodular vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-1 (VEGFR-1) level thyroid nodules and explore its relevance to ultrasound feature/pathological results.Methods: A total of 80 patients (62 women and 18 men) with thyroid nodules were included in this prospective study. Thyroid function tests, fine needle aspiration biopsies, ultrasonographic and scintigraphic evaluation were r...

Introduction: Non-typhoid salmonella as the causative agent of acute bacterial thyroiditis is rarely reported. We report a case with suppurative thyroiditis caused by salmonella infection.Case report: Fifty-year old woman had fewer and recurrent pain with swelling in the left region of the neck. Physical examination revealed the weight 78 kg, the height 167 cm, blood pressure 100/70 mmHg, pulse 78/min, the body temperature 37.6 degrees. Thyroid gland was...